Figure 2.

IEX-1^−/− Rag^−/− mice develop worse colitis than IEX-1 single KO mice after DSS treatment. IEX-1^−/− Rag^−/−, IEX-1^−/−, Rag^−/− and WT control mice were administered 3.5% DSS in drinking water for 7 days. Body weights were monitored daily and expressed as mean percentages ± SD of the initial weights. *, p<0.05 between double KO mice and single KO mice; and **, p<0.01 between double KO mice and WT mice (n = 6 in each group).