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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Mol Cancer Res. 2012 May 1;10(6):760–767. doi: 10.1158/1541-7786.MCR-11-0556

Figure 3.

Figure 3

Increased proliferation and apoptosis in IEX-1 KO IECs. Colon sections were labeled with BrdU antibody (A). Magnification 20X except for the bottom panels that are the enlarged (40x) areas of D5 marked by a white dashed line rectangle. An average number ± SD of BrdU-positive (brown) cells per 1 crypt was presented in (B). **, p<0.01 and n = 75. C. Apoptotic index in IECs. The indicated mice were treated with or without 3.5% DSS for 3 days, after which IECs were isolated and intracellularly stained by anti-cytokeratin and TUNEL following by flow cytometric analysis. The apoptotic index was expressed as % of TUNEL+ apoptotic cells over cytokeratin-positive cells by flow cytometry. n = 6 in each group.