Table 1.

Expression of different integrins in ASM, their potential ligands and change in expression in asthma.

Integrin	Expression in ASM	Potential ligands	Change in expression in asthma (human)	Reference
α1β1	Human, sheep, guinea pig	Collagen I, II, III, IV, laminin-111, fibronectin.	n.d.	[27–30]
α2β1	Human, guinea pig	Collagen I, IV, laminin-111, tenascin.	n.d.	[27–29, 31, 32]
α3β1	Human	Collagen I, fibronectin, laminin-211, laminin-221, laminin-322, laminin-511, laminin-521.	n.d.	[14, 27, 28]
α4β1	Human, sheep	Fibronectin, osteopontin, VCAM-1.	↑	[27, 28, 30, 33]
α5β1	Human, guinea pig	Fibronectin, osteopontin.	↑	[12, 27, 28, 32, 34, 35]
α6β1	Human	Laminin-111, laminin-411, laminin-511, laminin-521.	n.d.	[14, 28]
α6β4	Human	Laminin-322, laminin-511, laminin-521.	n.d.	[28]
α7β1	Human	Laminin-111, laminin-211, laminin-221.	n.d.	[14]
α8β1	Mouse	Fibronectin, tenascin, vitronectin	n.d.	[28]
α9β1	Human, guinea pig, mouse	ADAMs 1, 2, 3, 9, 15, factor XIII, L1-Cell adhesion molecule, osteopontin, tenascin, VCAM-1, von Willebrands factor.	↓	[28, 36, 37]
αvβ1	Human	Fibronectin.	↑	[28, 32]
αvβ3	Human	Fibrinogen, fibronectin, GSP, laminin, osteopontin, thrombospondin, vitronectin, von Willebrands factor.	n.d.	[27, 28, 32]
αvβ5	Human, mouse	Osteopontin, vitronectin	↑	[38]

n.d.: not determined.