TABLE 3.
Reproducibility of RTVue Optic Disc Measurements in Healthy Participants and Glaucoma Patients
| Healthy Participants | Glaucoma Patients | |||||||
|---|---|---|---|---|---|---|---|---|
| Optic Disc Parameters | Mean (95% CI) | Sw ± 1.96 se | CV % | ICC (95% CI*) | Mean (95% CI) | Sw ± 1.96 se | CV % | ICC (95% CI) |
| Disc area (mm2) | 1.6 (1.53 to 1.66) | 0 ± 0 | 0.27 | 1 (0.99 to 1) | 1.68 (1.59 to 1.78) | 0.01 ± 0 | 0.4 | 0.99 (0.98 to 0.99) |
| Cup area (mm2) | 0.34 (0.28 to 0.41) | 0.03 ± 0.01 | 23.5 | 0.98 (0.96 to 0.98) | 0.8 (0.67 to 0.93) | 0.05 ± 0.01 | 11.6 | 0.99 (0.98 to 0.99) |
| Rim area (mm2) | 1.25 (1.18 to 1.32) | 0.03 ± 0.01 | 2.68 | 0.97 (0.96 to 0.99) | 0.89 (0.81 to 0.96) | 0.05 ± 0.01 | 6.22 | 0.96 (0.94 to 0.97) |
| Rim volume (mm3) | 0.23 (0.2 to 0.26) | 0.02 ± 0 | 8.96 | 0.96 (0.94 to 0.98) | 0.12 (0.1 to 0.15) | 0.01 ± 0 | 12 | 0.97 (0.95 to 0.98) |
| Nerve head volume (mm3) |
0.38 (0.34 to 0.43) | 0.03 ± 0 | 7.11 | 0.97 (0.95 to 0.98) | 0.22 (0.19 to 0.25) | 0.02 ± 0 | 10.6 | 0.97 (0.95 to 0.98) |
| Cup volume (mm3) | 0.04 (0.03 to 0.06) | 0.01 ± 0 | 29.1 | 0.98 (0.97 to 0.99) | 0.23 (0.15 to 0.31) | 0.02 ± 0.01 | 21.3 | 0.99 (0.99 to 0.99) |
| Horizontal cup-todisc ratio | 0.47 (0.41 to 0.53) | 0.04 ± 0.01 | 14.1 | 0.93 (0.9 to 0.96) | 0.68 (0.63 to 0.73) | 0.04 ± 0.01 | 8.38 | 0.94 (0.91 to 0.96) |
| Vertical cup-todisc ratio | 0.42 (0.36 to 0.49) | 0.03 ± 0.01 | 15.8 | 0.96 (0.93 to 0.97) | 0.67 (0.62 to 0.72) | 0.03 ± 0.01 | 8.19 | 0.95 (0.93 to 0.97) |
| Cup-to-disc ratio | 0.21 (0.17 to 0.25) | 0.02 ± 0 | 22.2 | 0.97 (0.96 to 0.98) | 0.44 (0.39 to 0.49) | 0.03 ± 0.01 | 11.5 | 0.97 (0.96 to 0.98) |
CI = confidence interval; CV = coefficient of variation; ICC = intraclass correlation coefficient; Sw = within-subjects standard deviation.
Reproducibility is expressed as the Sw, the ICC, and the CV. Sw is defined as the square root of the within-subject variance (defined as the within-subjects sum of squares divided by its degrees of freedom). CV is calculated as the square root of the residual mean squared values of 3 measures, divided by mean.