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Renal histopathology and function(a). Periodic acid-Schiff staining of glomeruli, ×400 magnification (b). Masson's trichrome stained renal sections, ×400 magnification (c). Albuminuria in normal rat (NOR), spontaneously diabetic Torii rat (SDT) and SDT rat treated with 350 mg/kg metformin (MET). All data are expressed as mean ± SE (n = 8). *P < 0.01 versus NOR group, # P < 0.01 versus SDT group.
