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Expression of 8-OHdG in urine and renal tissues. (a) Uriany 8-OHdG excretion levels, (b) renal 8-OHdG levels, and (c) immunohistochemical stating for 8-OHdG in normal rat (NOR), spontaneously diabetic Torii rat (SDT) and SDT rat treated with 350 mg/kg metformin (MET). All data are expressed as mean ± SE (n = 8). *P < 0.01 versus NOR group, # P < 0.01, versus SDT group.
