Table 2.

Transcriptional repression of genes involved in translation in wild-type, gln3, and nil1 strains

Functional class	wt vs. wt + rap	gln3Δ vs. gln3Δ + rap	nil1Δ vs. nil1Δ + rap
Translation initiation (27 genes)	−2.2	−2.0  (−1.0)	−1.5  (+1.2)
Ribosome biogenesis (12 genes)	−5.8	−3.5  (−1.1)	−3.2  (+1.1)
rRNA processing (33 genes)	−4.8	−3.5  (−1.1)	−3.1  (+1.1)
RNA Pol I (7 genes)	−8.2	−5.0  (−1.1)	−6.1  (+1.1)
RNA Pol III (10 genes)	−3.2	−2.5  (+1.0)	−2.1  (+1.3)

Using publicly available, downloadable data (3), the geometric means of the sets listed were computed for PM38 (wild-type), PM71 (gln3), and MS221 (nil1) strains treated with 50 nM rapamycin for 30 min. The number of genes in each set is indicated beside the functional class in parentheses and the gene names within each set were previously described (3). To control for differences between the strains, the steady-state differences in transcript levels (the same geometric mean calculation as above) of the gln3 and nil1 strains were computed relative to wild-type and listed in parentheses besides the fold change caused by treatment with rapamycin. wt, wild type; rap, rapamycin.