Fig. 5.

Aortic atherosclerosis is markedly reduced by ezetimibe in obese, chronically inflamed Ldlr^−/− mice fed HFHS diet with added cholesterol only. (A) Aortic intimal and (B) sinus lesions. (C) Quantification of oil red-O staining and (D) Mac2 staining of aortic root lesions. (E) Representative photomicrographs of aortic root Oil Red-O and (F) Mac 2 staining. Open bars represent diets without ezetimibe; hatched bars represent diets admixed with ezetimibe (EZE). n = 10–15 per group, ^aP < 0.05 versus chow; ^bP < 0.001 versus chow; ^cP < 0.001 versus HFHS; ^dP < 0.001 versus HFHS+C by two-way ANOVA and post-hoc Bonferroni test.