TABLE 1.
Atorvastatin dose |
||||||||
10 mg |
20 mg |
40 mg |
80 mg |
|||||
Number of subjects | T/A 3,218 | A 3,274 | T/A 2,036 | A 2,027 | T/A 1,508 | A 1,559 | T/A 771 | A 674 |
Event | Number of events | |||||||
All Deaths | 50 | 19 | 21 | 17 | 12 | 12 | 10 | 11 |
Any CV cause | 30 | 13 | 11 | 9 | 4 | 6 | 4 | 7 |
Sudden death | 15 | 8 | 5 | 7 | 3 | 4 | 3 | 6 |
Fatal MI (not procedure related) | 6 | 2 | 2 | 2 | 0 | 1 | 0 | 1 |
Fatal stroke | 3 | 0 | 2 | 0 | 1 | 0 | 0 | 0 |
Hemorrhagic | 1 | 0 | 2 | 0 | 1 | 0 | 0 | 0 |
Ischemic | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Embolic | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fatal heart failure | 2 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Other vascular cause | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
Fatal MI (procedure related) | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Other cardiac cause | 1 | 1 | 2 | 0 | 0 | 0 | 1 | 0 |
Any non-CV cause | 19 | 6 | 9 | 6 | 6 | 4 | 6 | 4 |
Cancer | 12 | 5 | 4 | 3 | 4 | 4 | 4 | 2 |
Infection | 3 | 0 | 3 | 0 | 2 | 0 | 1 | 0 |
Trauma | 1 | 1 | 1 | 2 | 0 | 0 | 1 | 0 |
Suicide or homicide | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Other cause | 3 | 0 | 1 | 0 | 0 | 0 | 0 | 2 |
Reason unknown | 1 | 0 | 1 | 2 | 2 | 2 | 0 | 0 |
T/A: torcetrapib plus atorvastatin; A atorvastatin alone; CV: cardiovascular; MI: myocardial infarction.