. 2012 Jun 7;14(3):PCC.11r01298. doi: 10.4088/PCC.11r01298

Table 2.

Summary of Child and Adolescent Studies Comparing Side Effects in First-Generation Antipsychotics (FGAs) and Second-Generation Antipsychotics (SGAs)

Study	Journal	Type of Study	Findings
Correll et al,⁷ 2009	Journal of the American Medical Association	Large (N = 272), nonrandomized, multisite, controlled, 12-week trial examining cardiometabolic risk of SGAs in treatment-naive youth (aged 4–19 y) (SATIETY)	Aripiprazole, olanzapine, quetiapine, and risperidone were all associated with rapid and significant increases in body composition, but metabolic changes were less uniform. Actual metabolic syndrome and diabetes rarely developed
Sikich et al,¹⁶ 2008	American Journal of Psychiatry	Small (N = 119), 8-week, randomized trial comparing efficacy and safety of olanzapine and risperidone with molindone in treatment of early-onset schizophrenia and schizoaffective disorder (TEOSS)	No significant difference in response rates (molindone: 50%, olanzapine: 34%, risperidone: 46%). Olanzapine and risperidone associated with significantly greater weight gain (random assignment to olanzapine was discontinued). Molindone group had more self-reported akathisia
Fleischhaker et al,¹⁷ 2008	Journal of Neural Transmission	Small (N = 33), nonrandomized trial looking at weight and BMI for patients treated with clozapine, olanzapine, and risperidone over 45 wk	All groups experienced significant weight gain. Risperidone group reached weight gain plateau at 25–29 wk
Wonodi et al,¹⁸ 2007	Movement Disorders	Small (N = 118), nonrandomized trial with healthy control group (35 subjects) looking at tardive dyskinesia in children receiving antipsychotics	Nine percent exhibited tardive dyskinesia (11 of 118, including 5 of 81 receiving SGAs only) over more than 2 y
Sikich et al,³ 2004	Neuropsychopharmacology	Small (N = 50), 8-week, double-blind, randomized controlled trial comparing acute antipsychotic effect size and side effect propensity of risperidone and olanzapine to haloperidol in youth (aged 8–19 y)	Risperidone, olanzapine, and haloperidol were similarly effective; however, EPS were significant in all groups, as was weight gain

Abbreviations: BMI = body mass index, EPS = extrapyramidal side effects, SATIETY = Second-Generation Antipsychotic Treatment Indications, Effectiveness and Tolerability in Youth, TEOSS = Treatment of Early-Onset Schizophrenia Spectrum Disorders.