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In-line probing of enantiomeric ligands binding to AM1A. a) (4R,5S)-1 and (4S,5R)-1 and b) (4R,5S)-2 and (4S,5R)-2. Significant changes are summarized on secondary structure of AM1A for increased (shaded circle) and decreased (open circle) in-line cleavage. Significant changes were identified by comparing the slopes of the ligand-induced relative band intensity changes (See Supplementary Material).
