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Cutaneous changes in an animal model of Leishmania mexicana induced by ambient temperature. Lesions observed 6 months after infection of BALB/C mice with 1×106 parasites inoculated into the right footpad. (A and C) In the tropical climate, the expression revealed typical footpad inflammation. (B and D) In the mild climate, up to 50% of infected animals exhibited hair loss on the dorsum with minimal footpad inflammation.
