Table 1.

Temperature Influence on the Type of Lesion Development

	Temperature (°C)	Typical lesiona	Atypical lesionb	Fisher's exact test (p)	RR (95% confidence interval)
Exp 1	32	20/20	0/20	0.000	3.3 (1.7–6.5)
	22	6/20	14/20
Exp 2	32	22/22	0/22	0.000	2.1 (1.3–3.4)
	22	9/19	10/19
Exp 3	32	19/19	0/19	0.006	1.5 (1.1–2.0)
	22	14/21	7/21
Exp 4	32	20/20	0/20	0.001	1.9 (1.2–2.9)
	22	9/17	8/17
Exp 5	32	18/18	0/18	0.000	2.4 (1.2–4.7)
	22	5/12	7/12
Total	32	99/99	0/99	0.000	2.1 (1.7–2.6)
	22	43/89	46/89

^aTypical lesion: localized nodules of granulation tissue at the inoculation site.

^bAtypical lesion: generalized dermatosis in the dorsum and posterior extremities.

Parasite culture, and parasite detection by PCR, histology, or immunohistology were prepared in 1–2 mice from each experiment.