Table 2.
Association of Genotypes in VEGF Pathway With Pulmonary Complications
| Gene | SNP | Chromosome | Model of Inheritance | Discovery Set
|
Replication Set
|
Pooled Analysis
|
|||
|---|---|---|---|---|---|---|---|---|---|
| ORa (95% CI) | p Value | OR (95% CI) | p Value | OR (95% CI) | p Value | ||||
| FLT1 | rs9319425 | 13 | Additive | 1.48 (1.01–2.17) | 0.04 | 1.53 (1.05–2.24) | 0.03 | 1.50 (1.15–1.96) | 0.003 |
| NRAS | rs10489525 | 1 | Additive | 0.66 (0.41–1.05) | 0.08 | 0.56 (0.36–0.88) | 0.01 | 0.62 (0.46–0.86) | 0.004 |
| RAF1 | rs713178 | 3 | Recessive | 0.13 (0.02–1.14) | 0.07 | 0.30 (0.06–1.45) | 0.13 | 0.19 (0.05–0.70) | 0.01 |
| VEGFB | rs2429455 | 11 | Additive | 0.68 (0.43–1.05) | 0.08 | 0.78 (0.52–1.16) | 0.21 | 0.72 (0.54–0.97) | 0.03 |
| VEGFC | rs3775195 | 4 | Recessive | 2.57 (1.03–6.40) | 0.04 | 2.00 (0.66–6.05) | 0.22 | 2.18 (1.08–4.39) | 0.03 |
| FLT4 | rs307811 | 5 | Recessive | 2.33 (1.05–5.17) | 0.04 | 1.42 (0.64–3.13) | 0.39 | 1.84 (1.05–3.21) | 0.03 |
a
OR = odds ratio adjusted for age at operation, sex, intraoperative transfusion, % DLCO predicted, and chest wall resection.
DLCO = diffusing capacity of lung for carbon monoxide; CI = confidence interval; SNP = single nucleotide polymorphism; VEGF = vascular endothelial growth factor.