Table 1.
Effects of SH exposure on cardiovascular responses to hypercapnia and hypoxia in anesthetized rats
| 2h |
D5 |
||||
|---|---|---|---|---|---|
| VEH | SH | VEH | SH | ||
| Baseline (mmHg) | 106 ± 7 | 98 ± 11 | 108 ± 8 | 112 ± 12 | |
| MABP | Hypercapnia (Δ%) | 3 ± 2 | 5 ± 2 | 4 ± 2 | 6 ± 4 |
| Hypoxia (Δ%) | −42 ± 4* | −44 ± 5* | −44 ± 4* | −41 ± 7* | |
| Baseline (bpm) | 394 ± 11 | 406 ± 7 | 398 ± 12 | 412 ± 25 | |
| HR | Hypercapnia (Δ%) | 0 ± 1 | −3 ± 3 | −1 ± 0 | −2 ± 1 |
| Hypoxia (Δ%) | −2 ± 1 | 2 ± 2 | −1 ± 1 | −1 ± 2 | |
2h and D5 represent the data obtained at 2 h and on day 5 after vehicle (VEH) or high-dose sarin (SH, 4.0 mg h m−3) exposure. Data are expressed in percentage change from baseline “0” (Δ%) in response to hypercapnia or hypoxia.
*
P < 0.05, compared with baseline “0”; MABP, mean arterial blood pressure; HR, heart rate.