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. Author manuscript; available in PMC: 2012 Oct 8.
Published in final edited form as: J Med Chem. 2011 Jun 2;54(13):4350–4364. doi: 10.1021/jm2001025

Table 1.

HDAC3 and HDAC8 isoform inhibitory activity (IC50, nM) of isoxazole-based compounds 2a and 2b.

graphic file with name nihms295016u1.jpg
Compd Substituent R IC50±SD (nM) HDAC8/HDAC3a
HDAC3a HDAC8b
SAHA 27 ± 1.0 440 ± 21 16.3
1 1480 ± 220 7340 ± 22 4.96
2a N3 73 ± 15 707 ± 86 9.68
2b graphic file with name nihms295016t1.jpg 45 ± 1.3 651 ± 12 14.5
a

ratio of IC50 (nM)