Table 4.
Antiproliferative activity (EC50) of 2b, 3a, 3c and 3f towards HepG2, Hela and SH-SY5Y carcinoma cell lines.
| Compd | HepG2a | Helaa | SH-SY5Ya | ||||||
|---|---|---|---|---|---|---|---|---|---|
| 24 h | 48 h | 72 h | 24 h | 48 h | 72 h | 24 h | 48 h | 72 h | |
| SAHA | >50 μM | 8.4± 1.8 | 3.8± 1.1 | 43.0± 2.3 | 14.2± 1.4 | 4.7± 1.2 | > 50 μM | 25.6± 1.5 | 17.4± 8.3 |
| 2b | >50 μM | 11.5± 2.5 | 4.9± 1.4 | 26.5± 1.1 | 10.7± 1.2 | 4.7± 1.1 | > 50 μM | 32.2± 1.1 | 23.0± 1.1 |
| 3a | >50 μM | 12.6± 1.6 | 5.5± 1.4 | 46.6± 1.2 | 10.6± 2.3 | 5.5± 1.3 | > 50 μM | 22.7± 1.1 | 23.2± 2.2 |
| 3c | >50 μM | 12.7± 1.3 | 5.9± 1.3 | 38.3± 1.1 | 9.9± 1.4 | 4.6± 1.3 | > 50 μM | 23.6± 1.4 | 23.1± 1.3 |
| 3f | >50 μM | 24.3± 1.5 | 13.4± 1.4 | 30.6± 3.3 | 23.7± 1.1 | 15.0± 1.1 | > 50 μM | 35.9± 1.1 | 20.8± 3.1 |
a
EC50 in μM concentration