Table 1. IC50 values of the derivatives of AA005 in various human cancer and noncancerous cell lines.
No. | Compound | Structure | MW | IC50 (µM) | |||||
MCF7 | SGC7901 | HCT116 | HT29 | BEAS-2B | HLF | ||||
1 | AA005 | <$>\scale 75%\raster="rg1"<$> | 554.8 | 0.26±0.05 | 0.06±0.02 | 0.11±0.008 | 0.35±0.09 | >50 | 20.9±7.4 |
2 | AA090 | <$>\scale 75%\raster="rg2"<$> | 320.3 | >50 | >50 | >50 | >50 | >50 | >50 |
3 | AA091 | <$>\scale 75%\raster="rg3"<$> | 498.4 | 4.4±0.042 | 1.5±0.3 | 4.3±0.47 | 19.5±3.15 | >50 | >50 |
4 | AA093 | <$>\scale 75%\raster="rg4"<$> | 570.45 | 0.18±0.05 | 0.03±0.01 | 0.13±0.01 | 0.38±0.1 | 31.2±5.18 | 18.3±2.78 |
5 | AA101 | <$>\scale 75%\raster="rg5"<$> | 678.5 | 5.95±0.59 | 2±0.39 | 5.18±0.18 | >50 | >50 | >50 |
6 | AA102 | <$>\scale 75%\raster="rg6"<$> | 766.6 | 1.8±0.18 | 0.44±0.01 | 2.3±0.16 | 9.9±1.47 | >50 | 5.8±0.62 |
7 | AA103 | <$>\scale 75%\raster="rg7"<$> | 723.0 | 1.9±0.66 | 0.27±0.03 | 1.1±0.08 | 3.3±0.97 | 9.3±0.98 | 4.9±0.17 |
8 | AA104 | <$>\scale 75%\raster="rg8"<$> | 811.1 | 2.5±0.59 | 0.18±0.02 | 0.6±0.02 | 6.5±1.33 | >50 | 3.8±0.61 |
9 | AA105 | <$>\scale 75%\raster="rg9"<$> | 855.2 | 3±0.2 | 0.9±0.14 | 2.7±0.13 | 16.1±0.78 | >50 | >50 |