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. 2012 Oct 8;7(10):e47049. doi: 10.1371/journal.pone.0047049

Table 1. IC50 values of the derivatives of AA005 in various human cancer and noncancerous cell lines.

No. Compound Structure MW IC50 (µM)
MCF7 SGC7901 HCT116 HT29 BEAS-2B HLF
1 AA005 <$>\scale 75%\raster="rg1"<$> 554.8 0.26±0.05 0.06±0.02 0.11±0.008 0.35±0.09 >50 20.9±7.4
2 AA090 <$>\scale 75%\raster="rg2"<$> 320.3 >50 >50 >50 >50 >50 >50
3 AA091 <$>\scale 75%\raster="rg3"<$> 498.4 4.4±0.042 1.5±0.3 4.3±0.47 19.5±3.15 >50 >50
4 AA093 <$>\scale 75%\raster="rg4"<$> 570.45 0.18±0.05 0.03±0.01 0.13±0.01 0.38±0.1 31.2±5.18 18.3±2.78
5 AA101 <$>\scale 75%\raster="rg5"<$> 678.5 5.95±0.59 2±0.39 5.18±0.18 >50 >50 >50
6 AA102 <$>\scale 75%\raster="rg6"<$> 766.6 1.8±0.18 0.44±0.01 2.3±0.16 9.9±1.47 >50 5.8±0.62
7 AA103 <$>\scale 75%\raster="rg7"<$> 723.0 1.9±0.66 0.27±0.03 1.1±0.08 3.3±0.97 9.3±0.98 4.9±0.17
8 AA104 <$>\scale 75%\raster="rg8"<$> 811.1 2.5±0.59 0.18±0.02 0.6±0.02 6.5±1.33 >50 3.8±0.61
9 AA105 <$>\scale 75%\raster="rg9"<$> 855.2 3±0.2 0.9±0.14 2.7±0.13 16.1±0.78 >50 >50