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. 2012 Oct 8;7(10):e44686. doi: 10.1371/journal.pone.0044686

Figure 4. Concentration-response curves of the most effective and potent compounds.

Figure 4

(A) Concentration-response curves and (B) chemical structures of top four compounds with greatest maximum fold-increase in luminescent signal. (C) Concentration-response curves and (D) chemical structures of top four compounds with lowest EC50. AREc32 cells were treated with compound (0.01–30 µM) or DMSO vehicle. 24 hours after treatment, luciferase activity was assessed using the Steady-Glo luciferase assay with luminescence readout. The luminescence of each well was divided by the median luminescence of the DMSO vehicle control wells to generate the fold ARE activation.