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. 2012 Oct 8;7(10):e47013. doi: 10.1371/journal.pone.0047013

Figure 1. Neonatal overfeeding induces early-onset obesity and glucose intolerance in adulthood.

Figure 1

Body weight was measured in normal litters (NL) (○; n = 12) and small litters (SL) (•; n = 12) groups during lactation (A) and after weaning (B); Blood leptin was measured on P150 using RIA (C). Intraperitoneal glucose tolerance test (GTT, D) was performed on P120, and blood glucose levels were evaluated at 0 (fasting), 15, 30, 60 and 120 minutes after glucose loading of NL(○, n = 6) and SL(•, n = 6), corresponding AUC from 0 to 120 min, with the glucose level at 0 min considered as the baseline (E). Data were expressed as mean± SEM, and the significant difference between two groups was analyzed by Student t-tests, *P<0.05.