Figure 8. Connection between MYBBP1A, cell cycle genes and their function.

The figure depicts the connection between MYBBP1A, the genes regulating the cell cycle that are altered by MYBBP1A down-regulation and their function. In particular, the expression of red genes is increased in the absence of MYBBP1A, while those in blue are decreased. Thus, MYBBP1A induces the inhibitors of Cdc2/cyclinB and down-regulates the activators. Note that although the figure focuses on the G2/M phase, some of the genes function also at the G1/S (in particular CDKN1A). MYBBP1A might act by regulating the synthesis and/or activity of one or more of its partner transcription factors (cMyb, cJun, NF-kB). In fact, the level of cJun mRNA is increased upon MYBBP1A down-regulation (Table 4).