Table 1. Intra- and inter-observer reliability assessment for the volumetric measurement, made in a subset of 10 MS patients (thus 20 of each structure).

	Intra-observer reliability			Inter-observer reliability
Structure	Intraclass correlation coefficient*	95% confidence intervals	Significance	Intraclass correlation coefficient*	95% confidence intervals	Significance
Hippocampal volume	0.93	0.43–0.98	P<0.0005	0.86	0.67–0.94	P<0.0005
Thalamic volume	0.96	0.71–0.98	P<0.0005	0.83	0.17–0.94	P<0.0005
Mammillary body volume	0.92	0.78–0.97	P<0.0005	0.83	0.54–0.94	P<0.0005

^*Type A intraclass correlation coefficients using an absolute agreement definition.