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. 2012 Oct 8;7(10):e46724. doi: 10.1371/journal.pone.0046724

Figure 8. Dpn does not function downstream of Notch in maintaining type II NB self-renewal.

Figure 8

(A–A’) Expression of the intracellular domain of Notch (NIC) driven by insc-Gal4 ase-Gal80 in wild type type II NB lineages leads to an over-proliferation of type II NBs (e.g. arrowheads) and numerous smaller Ase- immature INPs. (B–B’) Expression of NIC driven by insc-Gal4 ase-Gal80 in dpn mutant type II NB lineages leads to a similar over-proliferation of type II NBs (arrowheads) and immature INPs. (C) Quantification of the number of type II NBs in 3rd instar larval brains with indicated genotypes (n = 6 in each group). *, p<0.05; n.s., stastically not significant.