Table 2. Regional differences in the BOLD response to masked-sad faces versus masked-happy faces (SN-HN) in patients with major depressive disorder and healthy controls.

Condition	Region	SN-HN
		Stereotaxic Coordinates			Cluster size*	Z-value#
		X	Y	Z
MDD>HC	L Hippocampus	−28	−24	−12	146*	3.60
	L Hippocampus	−28	−14	−14		3.47
	L Amygdala	−26	−3	−15		3.10∧
	R Amygdala/Anterior Inferotemporal C	38	−5	−22	12	3.18

Abbreviations: L = left; R = right; MDD = major depressive disorder; HC = healthy control; SN = masked-sad faces; HN = masked-happy faces; SN-HN = masked-sad versus masked-happy faces; C = cortex.

^*The cluster size was significant after applying a cluster threshold of k = 23 voxels using Monte Carlo simulations implemented in AFNI's AlphaSim program to correct for multiple comparisons.

^#The statistical t-values for these regions are reported in the text, while corresponding z-values are reported in the table.

^∧The peak amygdala coordinate varies slightly from those reported in our previous paper [8] because here we report results for SN-HN based on a different statistical approach (2×3 ANOVA).