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View full-text article in PMC

. 2012 Oct 8;7(10):e46529. doi: 10.1371/journal.pone.0046529

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© 2012 Wartman et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Murine APL requires the expression of PML-RARA in a multipotent progenitor, and cooperation of PML-RARA with myeloid restricted elements; expression of PML-RARA within promyelocytes is insufficient to cause leukemia. Orange ellipses indicate compartments with expression of the indicated genes used to direct expression in transgenic models. Red arrows indicate inappropriate self-renewal resulting from Ctsg-PML-RARA expression. Broken arrows indicate that multiple differentiation steps exist between indicated compartments. SLAM: lineage negative/Kit⁺/Sca-1⁺/CD150⁺/CD41⁻/CD48⁻. KLS: c-Kit⁺/lineage negative/Sca-1⁺. Pro: promyelocyte. PMN: polymorphic neutrophil. Concept after Lane and Ley [28].