Table 2. Prediction accuracy for the UniProt human protein variations given a PROVEAN score threshold of −2.282.
Variation type | Sensitivity | Specificity | Balanced accuracy |
Single amino acid substitutions | 78.39 | 79.11 | 78.75 |
Deletions | 95.86 | 67.53 | 81.70 |
Insertions | 92.73 | 80.33 | 86.53 |
Replacements | 92.41 | 61.02 | 76.71 |
Total | 79.04 | 79.06 | 79.05 |