Table 3. Number of the UniProt non-human protein variations and prediction accuracy given a PROVEAN score threshold of −2.282.

	Number of variations			Accuracy
Variation type	Deleterious	Neutral	Total	Sensitivity	Specificity	Balanced accuracy
Single amino acid substitutions	14117	16498	30615	80.22	75.33	77.75
Deletions	142	227	369	83.10	60.35	71.73
Insertions	34	137	171	76.47	73.72	75.10
Replacements	886	1029	1915	86.46	62.88	74.67
Total	15179	17891	33070	80.60	74.36	77.48