Figure 1. Effect of type I–III IFNs on IP10 release by human lung cells.

In the presence of TNFα, type I and type II, but not type III, interferons (IFNs) induce the release of IP10 from endothelial cells (HLMVECs; A), human pulmonary artery cells (HPASMCs; B) and human type II pneumocytes (A549 cells; C). Cells were treated with IFNs for 24 hours. Data are the mean ± standard error of the mean for n = 6–8. Within-group analysis was performed using one-way ANOVA followed by a Dunnett's post-test, where * indicates p<0.05 compared to control. Between-group analysis, for the effect of TNFα was performed using two-way ANOVA followed by Bonferroni's post-test where # indicates p<0.05.