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. 2012 Oct 8;7(10):e46779. doi: 10.1371/journal.pone.0046779

Figure 6. Effect of PEG-IFN α2a isoforms on IP10 release from HLMVECs.

Figure 6

Effect of different isoforms of PEG-IFN α2a on IP10 release from human lung microvascular endothelial cells (HLMVECs) co-treated with TNFα (10 ng/mL). Cells were treated for 24 hours with PEGIFNα2a or isoforms of PEGIFNα2a (K31, K134, K121) each at 10 ng/mL. Data are mean ± standard error of the mean for n = 7. Data have been normalized using IP10 release in the presence of 40KDa-PEGIFNα2a as 100%, and were analysed using a paired one sample t-test for each isoform or combination compared to PEGIFNα2a, where * indicates p<0.05. Intergroup analysis was performed using one-way ANOVA followed by Bonferroni's Multiple Comparison Test, where # indicates p<0.05.