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. Author manuscript; available in PMC: 2013 Nov 15.
Published in final edited form as: Dev Biol. 2012 Aug 25;371(2):180–190. doi: 10.1016/j.ydbio.2012.08.007

Figure 1. Paladin is expressed in premigratory and migratory neural crest cells.

Figure 1

(A–D) Cranial (B, C) and trunk (D) premigratory neural crest cells (open arrowhead) express Pald mRNA at 4 somites (4s). (E–M) At 8s (E–H), 10s (I–K), and 30s (L, M), Pald expression persists in hindbrain (G) and trunk premigratory neural crest cells (H, open arrowheads) and is maintained during delamination and migration of midbrain (F,I,J) hindbrain (K,L) and trunk neural crest cells (M; arrowheads). Pald expressing cells (J, arrowhead) are positive by immunofluorescence for the migratory neural crest marker HNK-1 (J’, arrowhead), confirming their identification as neural crest cells. Pald is also expressed in the basal surface of the neural tube (white arrows), blood vessels (black arrows), and dermomyotome (asterisk). A, E, I, dorsal view; L, dorsolateral view; B–D, F–H, J, K, M, transverse section at the level indicated in the accompanying whole mount. I, higher magnification view. Fg, foregut; nt, neural tube; o, otic placode.