Table 2.
Characteristics of patients with and without white matter disease. Data are presented at the proportion or the median (interquartile range). Statistics are by Mann-Whitney U test or χ2 as appropriate.
| Fazekas ≤2 N=88 |
Fazekas ≥3 N=22 |
P | |
|---|---|---|---|
| demographics | |||
| age | 52 (42, 64) | 68 (61–73) | <0.001 |
| female | 31/88 (35%) | 6/22 (27%) | NS |
| Caucasian | 78/88 (89%) | 21/22 (95%) | NS |
| atrial fibrillation | 11/88 (12%) | 4/22 (18%) | NS |
| hypertension | 42/88 (48%) | 16/22 (73%) | 0.036 |
| smoker | 38/88 (43%) | 5/22 (23%) | 0.079 |
| coronary heart disease | 19/88 (22%) | 6/22 (27%) | NS |
| diabetes | 21/88 (24%) | 6/22 (27%) | NS |
| characteristics of presenting stroke | |||
| NIHSS | 10 (3, 19) | 10 (4, 18) | NS |
| total infarct volume (cc) | 15.2 (1.5, 94.8) | 5.2 (0.5, 55.5) | NS |
| hemorrhagic conversion (any) | 18/88 (20%) | 4/22 (18%) | NS |
| prior infarct on imaging* | 16/88 (18%) | 10/22 (45%) | 0.007 |
| treatment | |||
| endovascular intervention | 13/88 (15%) | 1/22 (4%) | 0.198 |
| IV tPA | 19/88 (22%) | 7/22 (32%) | NS |
| hemicraniectomy | 7/88 (8%) | 1/22 (4%) | NS |
| stroke etiology | |||
| lacunar | 6/88 (7%) | 5/22 (23%) | 0.026 |
| cardioembolic | 23/88 (26%) | 6/22 (27%) | NS |
| large vessel disease | 15/88 (17%) | 2/22 (9%) | NS |
| dissection | 6/88 (7%) | 0/22 | NS |
| other | 25/88 (28%) | 4/22 (18%) | NS |
| unknown | 19/88 (22%) | 5/22 (23%) | NS |
| stroke related complications | |||
| infection by day 15 | 20/87 (23%) | 6/22 (27%) | NS |
| pneumonia by day 15 | 8/87 (9%) | 3/22 (14%) | NS |
NIHSS = National Institutes of Health Stroke Scale Score, IV tPA = intravenous tissue plasminogen activator,
*
signifies a radiological infarct, NS= not significant and signifies P≥0.200.