Table 4.
Correlates of the antibody titers to MBP, PLP and TT at multiple different time points after stroke. Data are log transformed and presented as Pearson’s rho.
| abMBP* | NIHSS | infarct volume | IL-10 | cortisol | lymphs | Th1 MBP | Th1 PLP | Th1 TT |
|---|---|---|---|---|---|---|---|---|
| Day 2 | −0.266 P=0.163 |
−0.263 P=0.127 |
−0.337 P=0.146 |
0.312 NS |
0.352 P=0.151 |
0.253 NS |
−0.058 NS |
0.157 NS |
| Day 4 |
−0.223 P=0.022 |
−0.171 NS |
−0.203 P=0.049 |
−0.072 NS |
0.047 NS |
−0.207 P=0.050 |
−0.098 NS |
−0.160 P=0.120 |
| Day 7 |
−0.271 P=0.008 |
−0.274 P=0.008 |
−0.331 P=0.001 |
−0.030 NS |
0.215 P=0.050 |
0.032 NS |
−0.033 NS |
−0.238 P=0.026 |
| Day 30 | −0.094 NS |
−0.186 P=0.084 |
−0.193 P=0.079 |
0.103 NS |
0.149 P=0.174 |
−0.188 P=0.105 |
−0.128 NS |
0.008 NS |
| Day 90 | 0.056 NS |
−0.112 NS |
0.009 NS |
0.123 NS |
−0.002 NS |
0.010 NS |
−0.091 NS |
−0.013 NS |
| Day 180 | −0.091 NS |
−0.072 NS |
−0.247 P=0.047 |
0.074 NS |
0.163 P=0.188 |
−0.194 P=0.148 |
0.042 NS |
0.038 NS |
| Day 365 | 0.035 NS |
−0.005 NS |
−0.057 NS |
−0.006 NS |
0.099 NS |
−0.061 NS |
−0.087 NS |
−0.233 P=0.138 |
| abPLP* | NIHSS | infarct volume | IL-10 | cortisol | lymphs | TH1 MBP | TH1 PLP | TH1 TT |
| Day 2 | −0.255 P=0.182 |
−0.150 NS |
−0.448 P=0.036 |
0.088 NS |
0.486 P=0.041 |
0.229 NS |
−0.073 NS |
−0.064 NS |
| Day 4 | −0.301 P=0.002 |
−0.238 P=0.014 |
−0.288 P=0.004 |
−0.262 P=0.008 |
0.065 NS |
−0.134 NS |
−0.065 NS |
−0.119 NS |
| Day 7 | −0.292 P=0.004 |
−0.173 P=0.097 |
−0.309 P=0.002 |
−0.172 P=0.103 |
0.251 P=0.021 |
−0.035 NS |
−0.075 NS |
−0.192 P=0.072 |
| Day 30 | −0.129 NS |
−0.214 P=0.046 |
−0.049 NS |
0.036 NS |
0.225 P=0.038 |
−0.035 NS |
0.041 NS |
−0.144 NS |
| Day 90 | −0.010 NS |
−0.104 NS |
−0.140 NS |
0.001 NS |
0.063 NS |
−0.027 NS |
−0.282 P=0.029 |
−0.305 P=0.015 |
| Day 180 | −0.149 NS |
−0.098 NS |
−0.064 NS |
0.149 NS |
0.209 P=0.092 |
0.050 NS |
0.245 P=0.083 |
0.118 NS |
| Day 365 | 0.069 NS |
0.162 NS |
−0.077 NS |
−0.154 NS |
0.125 NS |
0.177 NS |
0.018 NS |
0.131 NS |
| abTT** | NIHSS | infarct volume | IL-10 | cortisol | lymphs | TH1 MBP | TH1 PLP | TH1 TT |
| Day 2 | −0.182 NS |
−0.020 NS |
−0.489 P=0.024 |
0.197 NS |
−0.040 NS |
0.203 NS |
−0.133 NS |
−0.107 NS |
| Day 4 | −0.059 NS |
−0.062 NS |
−0.046 NS |
−0.010 NS |
−0.013 NS |
−0.179 0.092 |
−0.041 NS |
0.122 NS |
| Day 7 | −0.072 NS |
−0.044 NS |
−0.111 NS |
−0.161 P=0.128 |
−0.013 NS |
0.058 NS |
0.063 NS |
0.007 NS |
| Day 30 | −0.050 NS |
−0.080 NS |
0.135 NS |
−0.075 NS |
0.217 P=0.048 |
−0.001 NS |
0.041 NS |
−0.092 NS |
| Day 90 | −0.086 NS |
−0.013 NS |
−0.044 NS |
0.044 NS |
0.009 NS |
−0.115 NS |
−0.135 NS |
−0.136 NS |
| Day 180 | −0.106 NS |
−0.081 NS |
−0.033 NS |
0.178 P−0.143 |
0.177 P=0.155 |
0.079 NS |
−0.160 NS |
−0.108 NS |
| Day 365 | −0.154 NS |
−0.076 NS |
−0.087 NS |
0.075 NS |
0.222 P=0.121 |
−0.315 P=0.042 |
−0.103 NS |
−0.132 NS |
*
antibody titers to MBP and PLP are quantified by relative absorbance,
**
antibody titers to TT are quantified by IU/mL, abMBP=antibody titer to myelin basic protein, abPLP=antibody titer to proteolipid protein, abTT=antibody titer to tetanus toxoid, NIHSS=National Institutes of Health Stroke Scale Score, IL=interleukin, lymphs=lymphocytes, NS=not significant (P≥0.200).