Skip to main content
. Author manuscript; available in PMC: 2013 Oct 3.
Published in final edited form as: Cell Metab. 2012 Sep 13;16(4):420–434. doi: 10.1016/j.cmet.2012.06.017

Figure 1.

Figure 1

Sphingolipid metabolism. Key intermediates are boxed and enzymes are shown in green highlights. Key steps of regulation are indicated with asterisks. *- regulation at the step at the rate-limiting enzyme SPT. Please refer to figure 2 for details. **- ceramide transport from the ER to the Golgi needs the CERT protein which is subject to regulation by cellular signaling pathways. ***- intracellular S1P is secreted by the Spns2 transporter to mediate its extracellular actions on S1P receptors. Intracellular S1P is a key intermediate in the formation of phospholipids (via phosphoethanolamine) and triglycerols (via palmitoyl CoA).