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. Author manuscript; available in PMC: 2013 Sep 13.
Published in final edited form as: Psychiatry Res. 2012 Sep 13;203(2-3):111–125. doi: 10.1016/j.pscychresns.2012.02.003

Table 2.

a: Meta-analysis with ratio data, schizophrenia
Region number
of studies		 Metabolite SMD [95% CI] p
value		 Heterogeneity
(I2)
Hippocampus 8 NAA/Cr −0.72 [−1.20, −0.25] <0 .01 74%
5 Cho/Cr −0.28 [−0.54, −0.02] 0.03 0%
Thalamus 9 NAA/Cr −037 [−0.58, −0.17] <0 .01 6%
6 Cho/Cr −0.02 [−0.34, 0.30] 0.91 42%
Basal ganglia 8 NAA/Cr −0.16 [−0.46, 0.13] 0.28 32%
6 Cho/Cr 0.13 [−0.22, 0.48] 0.47 37%
Frontal lobe 16 NAA/Cr −0.22 [−0.39, −0.06] < 0.01 0%
13 Cho/Cr 0.09 [−0.24, 0.41] 0.61 68%
DLPFC 3 NAA/Cr 0.14 [−0.72, 1.00] 0.75 86%
2 Cho/Cr −0.15 [−0.73, 0.42] 0.60 58%
Temporal lobe 7 NAA/Cr −0.64 [−1.09, −0.19] <0 .01 77%
b: Meta-analysis with ratio data, bipolar disorder
Region number
of studies		 Metabolite SMD [95% CI] p
value		 Heterogeneity
(I2)
Hippocampus 4 NAA/Cr −0.96 [−1.37, −0.55] <0.01 0%
3 Cho/Cr −0.37 [−0.84, 0.11] 0.13 0%
Basal ganglia 7 NAA/Cr −0.02 [−0.55, 0.51] 0.95 69%
6 Cho/Cr −0.04 [−0.62, 0.54] 0.89 70%
ACC 5 NAA/Cr −0.59 [−1.18, 0.01] 0.06 75%
6 Cho/Cr 0.00 [−0.00, 0.01] 0.52 43%
DLPFC 6 NAA/Cr −0.03 [−0.42, 0.36] 0.88 49%
5 Cho/Cr 0.05 [−0.23, 0.33] 0.74 6%