Skip to main content
. Author manuscript; available in PMC: 2013 Aug 29.
Published in final edited form as: Trends Cardiovasc Med. 2012 Aug 29;22(4):98–105. doi: 10.1016/j.tcm.2012.07.003

Figure 1.

Figure 1

Multiple stimuli increase (indicated by +) or decrease (indicated by −) PGC-1α expression. PGC-1α coactivates PPAR and ERR transcription factors and thereby regulates the expression of genes involved in mitochondrial fatty acid import and oxidation. In addition, PGC-1α regulates the expression of nuclear encoded oxidative phosphorylation (OXPHOS) subunits via coactivation of ERRs, NRF-1 and NRF-2. NRF-1 and NRF-2 also bind to the promoter of the mitochondrial transcription factor A (TFAm) and coordinates the transcription of the nuclear and mitochondrial genome.