Table 2.

Multivariate analysis of disease-free survival and overall survival in all population

	Disease-free survival			Over survival
Variables	HR	95% CI	P-value	HR	95% CI	P-value
Age, years (≤35 vs >35)	0.67	0.58–0.77	<0.0001	0.75	0.61–0.92	0.005
Tumor size, cm (≤ 2 vs >2)	1.82	1.55–2.14	<0.0001	1.83	1.46–2.31	<0.0001
Node status (Neg. versus Pos.)	1.46	1.25–1.70	<0.0001	1.45	1.16–1.83	0.001
Stage (I/II vs III)	1.81	1.56–2.09	<0.0001	2.21	1.80–2.70	<0.0001
Hormone receptor status (Neg. versus Pos.)	0.82	0.72–0.93	0.002	0.65	0.55–0.78	<0.0001
HER–2 status (Neg. versus Pos.)	1.15	1.11–1.18	<0.0001	1.09	1.05–1.14	<0.0001
Histologic grade (I/II vs III)	1.30	1.21–1.38	<0.0001	1.31	1.19–1.44	<0.0001
Vascular invasion (No versus Yes)	1.77	1.37–2.28	<0.0001	1.80	1.29–2.51	0.001
Ki–67 (14% vs >14%)	0.94	0.89–1.00	0.032	0.85	0.76–0.95	0.004

HR and 95% confidence intervals (CIs) were calculated using Cox regression analysis. HER-2, human epidermal growth factor receptor 2; HR, hazard ratio; Neg, negative; Pos, positive.