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. 2012 Aug 29;32(35):11930–11941. doi: 10.1523/JNEUROSCI.0178-12.2012

Figure 1.

Figure 1.

Nuclear expression of epigenetic regulatory proteins associated with fear extinction. a, There was a significant increase in the expression of methyl-CpG binding protein, MECP2 (microarray +1.7-fold change, Western blot validation, F(2,11) = 5.55, p < 0.05, Tukey's post hoc test, FC-No EXT vs EXT, p < 0.05). b, There was also a significant decrease in the expression of the histone deacetylase HDAC2 after fear extinction training (microarray −0.67-fold change, Western blot validation, F(2,11) = 6.31, p < 0.05, Tukey's post hoc test, FC-No EXT vs EXT, p < 0.05). c, Expression of the histone modification H3K9me2 was also decreased after extinction training (microarray −0.43-fold change, Western blot validation, F(2,11) = 15.21, p < 0.01, Tukey's post hoc test, FC-No EXT vs EXT, p < 0.05). d, We found a significant increase in the expression of PCAF (microarray +1.65-fold change, Western blot validation, F(2,11) = 5.86, p < 0.05, Tukey's post hoc test, FC-No EXT vs EXT, p < 0.05) and a corresponding decrease in both CBP and p300 after extinction training. e, CBP microarray (−0.68-fold change, Western blot validation, F(2,11) = 15.21, p < 0.01, Tukey's post hoc test, FC-No EXT vs EXT, p < 0.05). f, p300 microarray (−0.68-fold change, Western blot validation F(2,11) = 11.09, p < 0.01, Tukey's post hoc test, FC-No EXT vs EXT p < 0.01). *p < 0.05; **p < 0.01.