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. 2012 Aug 29;32(35):11930–11941. doi: 10.1523/JNEUROSCI.0178-12.2012

Figure 6.

Figure 6.

Fear extinction learning induces a transient increase in ATF4 binding to the zif268 promoter and decreases zif268 mRNA expression in vivo. a, Relative to fear-conditioned mice, fear-extinction learning led to increased ATF4 binding to the zif2568 gene promoter [F(3,15) = 5.40, p < 0.05; Tukey's post hoc test, FC-No EXT (30 min) vs EXT (30 min), p < 0.05]. b, This was associated with decreased zif268 mRNA expression at the same time point [F(3,30) = 18.90, p < 0.01; Tukey's post hoc test, FC-No EXT (30 min) vs EXT (30 min), p < 0.05]. c, ATF4 binding to the zif268 promoter after fear-extinction training was inhibited when training occurs in the presence of the PCAF inhibitor H3-CoA-20-Tat (50 μm). d, In the presence of the PCAF inhibitor, fear-extinction learning did not lead to decreased zif268 mRNA expression. *p < 0.05; **p < 0.01.