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. 2012 Oct 9;2:717. doi: 10.1038/srep00717

Figure 1.

Figure 1

(a) Substrate-bound human C-domain sACE crystal structure.C-domain ACE (cyan) in cartoon representation, with Ang II in red sticks, glycosylated carbohydrates in yellow sticks. The catalytic zinc ion is shown as a green sphere. (b) BPPb- bound C-domain ACE crystal structure. C-domain ACE (cyan) in cartoon representation, with BPPb in orange sticks. (c) Loss of the zinc ion coordination upon C-domain ACE binding to BPPb. Left panel, zinc coordination in the Ang II-bound C-domain ACE, with a classical tetrahedral motif, bound zinc ion as green sphere. Right panel, movement of the coordinating His383. (d) Conformational changes of C-domain ACE upon BPPb binding. Ang II and BPPb-bound C-domain ACE (cyan and blue respectively) in cartoon representation. Ang II and BPPb are shown as as red and orange sticks respectively. The zinc ion is only present in the Ang II-bound structure. Movement of the α1 and α2 helices is highlighted.