Table 2. Hydrogen bond interactions of C-domain on human sACE with Ang II and BPPb peptides.

	Ang II peptide						BPPb peptide
Position (peptide)	Ligand atome	Interacting atom from the C-domain sACE (and the zinc ion)	Distance (Å)	Ligand atomf	Interacting atom from the C-domain sACE (and the zinc ion)	Distance (Å)	Ligand atom	Interacting atom from the C-domain of sACE	Distance (Å)
P9							pE1 N	K118 O	3.0
P8							G2 N	D121 N	2.9
P5							P5 O	Y360 OH	2.5
P4	D1 O	D358 N	2.9	R2 O	D358 N	2.9
							R6 NH1	S516 O	2.9
							R6 NH2	S517 O	2.7
P2	V3 N	A356 O	2.9	Y4 N	A356 O	2.9	K8 O	A356 O	3.0
	V3 O	A356 N	2.8	Y4 O	A356 N	2.7	K8 O	A356 N	2.9
							K8 NZ	E403 OE2	2.6
P1	Y4 O	H383 NE2	2.9
	Y4 O	H387 NE2	3.1
				I5 O	Y523 OH	3.2	I9 O	Y523 OH	3.0
	Y4 O	Zinc ion	2.0	I5 O	Zinc ion	2.2
P1′	I5 O	H353 NE2	3.3	H6 O	H353 NE2	2.7
				H6 N	A354 O	3.0
	I5 O	H513 NE2	2.7	H6 O	H513 NE2	2.8	P10 O	H513 NE2	3.0
P2′	H6 O	Q281 NE2	2.8	P7 O	Q281 NE2	3.0	P11 O	Q281 NE2	3.1
	H6 O	K511 NZ	2.7	P7 O	K511 NZ	2.7	P11 O	K511 NZ	2.8
	H6 O	Y520 OH	2.7	P7 O	Y520 OH	2.8	P11 O	Y520 OH	2.5

^eAngiotensin II [1–6]. ^fAngiotensin II [2–7].