Table 2.
IC50 (μM) of cisplatin, ligand 1, phosphine oxide TPA=O and metal complexes 2-8 complexes in human cell lines.a All compounds were dissolved in 1% of DMSO and diluted with water before addition to cell culture medium for a 24 h incubation period. Cisplatin was dissolved in water.
| Jurkat | PBMC | DU-145 | |
|---|---|---|---|
| Cisplatinb | 7.4±2.1 | 500±18 | 79.2±15.8 |
| TPA=O | >500 | >500 | >500 |
| 1 | >500 | >500 | >500 |
| 2 | 8.1±1.1 | 209±11 | 49.3±3.1 |
| 3 | 10.5±1.8 | 118±11 | 96.2±12 |
| 4 | 142±9 | 186±9 | 135±27 |
| 5 | 89±18 | >500 | 187±16 |
| 6 | 322±29 | >500 | 318±20 |
| 7 | 101±20 | 298±14 | 299±25 |
| 8 | 374±40 | >500 | 448±38 |
a
Data are expressed as mean ± SD (n =3).
b
Values obtained by the same MTT assay conditions (ref 34).