Table 1.

Chemical/Physiological/Pharmacological Parameters of BCS class II drugs for GastroPlus™ Simulation

		Ibuprofen	Ketoprofen
MW		206.3	254.3
Dose	mg	600a	50f
Dose number		63#	197#
Dose volume	mL	250	250
Solubility (pH1.2)	mg/mL	2.1 × 10-2b	5.1 × 10-2b
logP		4.0c	2.8g
pKa		4.5d	3.7b
Mean precipitation time	sec	900	900
Human Peff	× 10-4 cm2/sec	4.10*	8.70h
Body weight	kg	70	70
Vc	L/kg	0.2e	0.4f
Total clearance	L/h/kg	0.10a	0.06f

Vc; Volume of Central Compartment

^#Calculated by GastroPlus™ 7.0

^*Calculated by ADMET Predictor

^aRef [13]

^bRef [23]

^cRef [20]

^dRef [21]

^eRef [19]

^fRef [22]

^gRef [25]

^hRef [24]