Table 2.
Absorption scale factor (ASF), fluid volume (mL) and pH settings at different intestinal sites for simulation
| pH condition for the simulation | ||||||
|---|---|---|---|---|---|---|
| Intestinal | Default pH | 0.5 lower pH | 1.0 lower pH | 2.0 lower pH* | Fluid volume | ASF |
| Duodenum | 6.0 | 5.5 | 5.0 | 4.0 | 41.6 | 7.0 |
| Jejunum1 | 6.2 | 5.7 | 5.2 | 4.2 | 154.2 | 10.0 |
| Jejunum2 | 6.4 | 5.9 | 5.4 | 4.4 | 122.3 | 7.0 |
| Ileum1 | 6.6 | 6.1 | 5.6 | 4.6 | 94.3 | 2.7 |
| Ileum2 | 6.9 | 6.4 | 5.9 | 4.9 | 70.5 | 2.6 |
| Ileum3 | 7.4 | 6.9 | 6.4 | 5.4 | 49.8 | 2.5 |
| Caecum | 6.4 | 6.4 | 6.4 | 6.4 | 47.5 | 0.1 |
| Asc Colon | 6.8 | 6.8 | 6.8 | 6.8 | 50.3 | 0.3 |
*
Simulations with lowered pH numbers were strictly hypothetical to see the effect of intestinal pH for drug absorption.