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Simulated Cmax and AUC0-inf of IR ketoprofen at different intestinal pHs
| An IR dose |
||||
|---|---|---|---|---|
| Release Rate | Default pH | 0.5 lower pH | 1.0 lower pH | 2.0 lower pH |
| Cmax (× 10-1 μg/mL) | 16.7 ± 1.1 | 16.6 ± 1.0 | 16.5 ± 1.2 | 15.3 ± 1.5 |
| AUC0-inf (μg-h/mL) | 11.7 ± 0.8 | 12.2 ± 0.9 | 12.0 ± 1.0 | 11.7 ± 1.0 |
Data reported as mean ± SD.
