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. 2012 Oct 5;124(Pt 3):153–164. doi: 10.1042/CS20120190

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© 2013 The Author(s) The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Non-Commercial Licence (http://creativecommons.org/licenses/by-nc/2.5/) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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SIRT1 exerts renoprotective effects by conferring resistance to cellular stresses such as hypoxia, reducing interstitial fibrosis, inhibiting tubular and glomerular cell apoptosis and inflammation, inducing autophagy, and regulating Na⁺-handling, blood pressure and renal lipid metabolism.