Figure 4.
Ultrasonic molecular imaging of tumor angiogenesis in breast cancer. Transverse ultrasound image of orthotopically implanted human breast adenocarcinoma xenograft (MDA-MB-231 cells) in nude mouse imaged following intravenous administration of 5×107 VEGFR2-targeted contrast microbubbles (BR55). Note strong imaging signal in breast cancer compared to surrounding normal tissue due to increased angiogenesis and up-regulation of VEGFR2 on angiogenic vascular endothelial cells in breast cancer. Scale bar =3 mm