Table 5.

Effects of MP and FK506 on HBV Gene Sequences in HepG2.2.15 Cells

	HBV gene sequence
	Amino acid mutations in S region		Amino acid mutations in P region
Concentration	MP	FK506	MP	FK506
Control	No mutation	No mutation	No mutation	No mutation
Low concentration	K2Q; P211L; L213M; C221G	C221G	rtK148E; rtF151I; rtA307G; rtY339T; rtD354G; rtA355R; rtT356N; rtP357K	No mutation
High concentration	L213M L215I	T5I L213M L213F C221V	rtY335N; rtG361G; rtM364H; rtH367S; rtQ368A; rtV370A; rtR371L; rtG372E; rtP373T; rtS374R; rtA375L; rtP376L; rtL377C; rtP379S	rtP138K; rtK154E; rtI169T; rtP170L; rtT184I; rtD354G; rtA355R; rtT356N; rtP357K; rtA382G

Underlined mutations in the P region are at nucleoside analogue-resistant sites.

MP, methylprednisolone; FK506, tacrolimus; HBV, hepatitis B virus.