Table 7.
Effects of Missense Mutations in the S Region on Mutations in the RT Region of the Overlapping P Gene in Patients
| No | Missense mutations in the S region before transplantation (aa) | Mutations in the RT region of the overlapping P gene before transplantation (aa) | Frequency (%) | Missense mutations in the S region after transplantation (aa) | Mutations in the RT region of the overlapping P gene after transplantation (aa) | Frequency (%) |
|---|---|---|---|---|---|---|
| 1 | G10A | rtR18T | 28.57% (4/14) | T5A | rtP13R | 21.43% (3/14) |
| 2 | A45T | rtS53N | 7.143% (1/14) | F8S | rtI16T | 7.143% (1/14) |
| 3 | A45A | rtT54S | 14.29% (2/14) | G10A | rtR18T | 7.143% (1/14) |
| 4 | T47A | rtH55R | 21.43% (3/14) | A45T | rtS53N | 7.143% (1/14) |
| 5 | T47K | rtH55Q | 14.29% (2/14) | T47A | rtH55R | 21.43% (3/14) |
| 6 | T57I | rtN65Q | 7.143% (1/14) | T47K | rtH55Q | 7.143% (1/14) |
| 7 | S64C | rtL72V | 7.143% (1/14) | T57I | rtN65Q | 7.143% (1/14) |
| 8 | F69L | rtS78T | 7.143% (1/14) | S64C | rtL72V | 7.143% (1/14) |
| 9 | L98V | rtS106C | 35.71% (5/14) | F69L | rtS78T | 7.143% (1/14) |
| 10 | L110F | rtT118I | 7.143% (1/14) | L98V | rtS106C | 7.143% (1/14) |
| 11 | I113S | rtN121I | 7.143% (1/14) | L110F | rtT118I | 7.143% (1/14) |
| 12 | I126S | rtD134E | 28.57% (4/14) | I113S | rtN121I | 7.143% (1/14) |
| 13 | T131N | rtN139K | 21.43% (3/14) | I126S | rtD134E | 35.71% (5/14) |
| 14 | S143T | rtF151Y | 14.29% (2/14) | T131N | rtN139K | 21.43% (3/14) |
| 15 | G145R | rtR153Q | 14.29% (2/14) | S143T | rtF151Y | 7.143% (1/14) |
| 16 | T160K | rtK168K | 7.143% (1/14) | G145R | rtR153Q | 14.29% (2/14) |
| 17 | L176Q | rtT184I | 7.143% (1/14) | L176Q | rtT184I | 7.143% (1/14) |
| 18 | V184A | rtR192C | 7.143% (1/14) | V184A | rtR192C | 14.29% (2/14) |
| 19 | I195M | rtM204V | 14.29% (2/14) | I195M | rtM204V | 14.29% (2/14) |
| 20 | F212V | rtL220V | 28.57% (4/14) |
M198I V199V |
rtV207I | 14.29% (2/14) |
| 21 | F212L | rtF221V | 21.43% (3/14) | F212V | rtL220V | 21.43% (3/14) |
Mutations in the “a” determinant region and S gene outside the “a” determinant region are shown in italics. Underlined mutations are related to immune evasion or nucleoside analogue resistance. Bold mutations were different before and after transplantation.