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The ubiquitin ligase complexes SCF and APC/C in ubiquitin-mediated proteolysis of regulatory molecules essential for cell cycle control. Two major ubiquitin ligase complexes, SCF and APC/C, are responsible for the specific ubiquitination of cell cycle regulators through the proteasome targeted degradation. SCF ligase complexes control the G1 to S transition, while APC/C ligases mediate the onset and exit of mitosis.
