Table 2.
Factors Associated With Long-Term Efavirenz Exposure Among 87 Subjects From the Women's Interagency HIV Study
| Factor | Effect on Hair (95% CI) | P | Distribution of Factor in Sample |
|---|---|---|---|
| Oranges or orange juice in preceding 5 d | 1.19 (.88–1.60) | .27 | Consumed by 57 (65.5%) |
| For every doubling of ALT level | 1.10 (.93–1.30) | .25 | Median ALT, 23 IU/L (range, 8–117 IU/L) |
| CYP2B6 516 G>T (rs3745274) | … | 38 (43.7%), 0 doses | |
| 0 or 1 dose of minor allele (GG, GT) | 1.00 | 1.0 × 10−10 | 36 (41.4%), 1 dose |
| 2 doses of minor allele (TT) | 3.2 (2.2–4.7) | 13 (14.9%), 2 doses | |
| CYP2B6 983 T>C (rs28399499) 0 doses of minor allele (TT) 1 or 2 doses of minor allele (TC,CC) | …1.001.70 (1.09–2.7) | .021 | 77 (88.5%), 0 doses9 (10.3%), 1 dose1 (1.1%), 2 doses |
| ABCB1 haplotype (2 SNPS: rs7779562 and rs4148745) | … | 11 (12.6%), 0 doses | |
| 0 doses of the haplotype | 1.00 | .31 | 38 (43.7%), 1 dose |
| 1 or 2 doses of the haplotype | 1.24 (.82–1.88) | 38 (43.7%), 2 doses | |
| Self-reported adherence≤74%75–94%≥95% | 1.00.94 (.45–1.96)1.10 (.56–2.2) | .88.77 | 4 (4.6%)14 (16.1%)69 (79.3%) |
Long-term exposure was evaluated in terms of the hair level per dose.
Abbreviations: ALT, alanine amino transferase; AUC, area under the concentration-time curve; CI, confidence interval.